Vulnerability of SARS-CoV-2 and PR8 H1N1 virus to cold atmospheric plasma activated media

O.D. Cortázar, A. Megia-Macías, S. Moreno Fernández, A. Brun Torres, E. Gómez-Casado

Scientific Reports Vol. 12, pp. 263-1 - 263-12

Summary:

Cold Atmospheric Plasma (CAP) and Plasma Activated Media (PAM) are effective against bacteria, fungi, cancer cells, and viruses because they can deliver Reactive Oxygen and Nitrogen Species (RONS) on a living tissue with negligible damage on health cells. The antiviral activity of CAP against SARS-CoV-2 is being investigated, however, the same but of PAM has not been explored despite its potential. In the present study, the capability of Plasma Activated Media (PAM) to inactivate SARS-CoV-2 and PR8 H1N1 influenza virus with negligible damage on healthy cells is demonstrated. PAM acted by both virus detaching and diminished replication. Furthermore, the treatment of A549 lung cells at different times with buffered PAM did not induce interleukin 8 expression, showing that PAM did not induce inflammation. These results open a new research field by using PAM to the development novel treatments for COVID-19, influenza, and other respiratory diseases.

Spanish layman's summary:

Se abre un campo de investigación para el tratamiento de la COVID-19 y la gripe y para el control de la propagación de virus respiratorios. Investigadores españoles demuestran la vulnerabilidad de los virus SARS-CoV-2 y PR8 H1N1 a los medios activados con plasma atmosférico. Sci Rep 12, 263 (2022)

English layman's summary:

New results open a research field by using Plasma Activated Media (PAM) to treat COVID-19 and influenza and to control the spread of respiratory viruses. Spanish researchers demonstrate the vulnerability of the SARS-CoV-2 and PR8 H1N1 viruses to plasma activated media. Sci Rep 12, 263 (2022)

Keywords: Plasma Medicine, Plasma Activated Media, Covid-19

JCR Impact Factor and WoS quartile: 4,600 - Q2 (2022); 3,800 - Q1 (2023)

DOI reference: https://doi.org/10.1038/s41598-021-04360-y

Published on paper: December 2022.

Published on-line: January 2022.

Citation:
O.D. Cortázar, A. Megia-Macías, S. Moreno Fernández, A. Brun Torres, E. Gómez-Casado, Vulnerability of SARS-CoV-2 and PR8 H1N1 virus to cold atmospheric plasma activated media. Scientific Reports. Vol. 12, pp. 263-1 - 263-12, December 2022. [Online: January 2022]